2. Neuronal Signaling
  3. Amyloid-β
  4. Aβ-IN-10

Aβ-IN-10 (Compound Alz -5) is a bifunctional copper chelator and an inhibitor for beta-amyloid (Aβ), that interacts with Aβ aggregates and reduces the neurotoxicity. Aβ-IN-10 exhibits antioxidant efficacy, reveals moderate cytotoxicity with the presence of CuCl2 in SH-SY5Y and HepG2 with IC50 of 65.5, 31.2 μM. Aβ-IN-10 reduces the increase of cell stiffness caused by Aβ.

For research use only. We do not sell to patients.

Aβ-IN-10 Chemical Structure

Aβ-IN-10 Chemical Structure

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Aβ-IN-10 Related Antibodies

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Description

Aβ-IN-10 (Compound Alz -5) is a bifunctional copper chelator and an inhibitor for beta-amyloid (Aβ), that interacts with Aβ aggregates and reduces the neurotoxicity. Aβ-IN-10 exhibits antioxidant efficacy, reveals moderate cytotoxicity with the presence of CuCl2 in SH-SY5Y and HepG2 with IC50 of 65.5, 31.2 μM. Aβ-IN-10 reduces the increase of cell stiffness caused by Aβ[1].

Molecular Weight

557.78

Formula

C30H35N7S2
SMILES

CC(/C(C)=N/NC(NC1=CC=C(/C=C/C2=CC=C(N(C)C)C=C2)C=C1)=S)=N\NC(NCCC3=CC=CC=C3)=S
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Aβ-IN-10 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Aβ-IN-10Amyloid-ββ-amyloid peptideAβAbetaNeuroblastomaSH-SY5YHepG2Alzheimer's diseaseInhibitorinhibitorinhibit

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