2. Neuronal Signaling Stem Cell/Wnt
  3. γ-secretase
  4. Aβ42-IN-1 free base

Aβ42-IN-1 free base (compound 1v) is an orally active, high brain exposure γ-secretase modulator. Aβ42-IN-1 free base potently reduces Aβ42 levels with an IC50 value of 0.091 µM, and significantly reduces brain Aβ42 levels in mice. Aβ42-IN-1 free base is a promising compound for the treatment of Alzheimer’s disease.

For research use only. We do not sell to patients.

Aβ42-IN-1 free base Chemical Structure

Aβ42-IN-1 free base Chemical Structure

CAS No. : 2434633-17-5

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Aβ42-IN-1 free base Related Antibodies

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Description

Aβ42-IN-1 free base (compound 1v) is an orally active, high brain exposure γ-secretase modulator. Aβ42-IN-1 free base potently reduces Aβ42 levels with an IC50 value of 0.091 µM, and significantly reduces brain Aβ42 levels in mice. Aβ42-IN-1 free base is a promising compound for the treatment of Alzheimer’s disease[1].

In Vivo

Aβ42-IN-1 free base treatment shows that the CLint value is 84.7 µL/min/mg protein[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nonfasted 8-week-old male ddY mice[1]
Dosage: 30 mg/kg
Administration: p.o. (Pharmacokinetic Analysis)
Result: The CLint is 84.7 µL/min/mg protein.
Molecular Weight

462.54

Formula

C29H26N4O2
CAS No.
SMILES

O=C(C1=NC=C(C2=C(C)N=C3C(OCC4=CC=C(C5=CC=CC=C5)C=C4)=CC=CN32)C=C1)NCC
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Aβ42-IN-1 free base Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Aβ42-IN-12434633-17-5γ-secretaseGamma secretaseoralAβ42Alzheimer’sdiseasehighbrainexposureInhibitorinhibitorinhibit

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