2. Apoptosis Immunology/Inflammation MAPK/ERK Pathway
  3. Apoptosis COX TNF Receptor p38 MAPK
  4. Balanophonin

Balanophonin is an anti-inflammatory and anti-cancer agent. Balanophonin inhibits microglial activation and neurodegeneration via inhibiting activated microglia-induced apoptosis.

For research use only. We do not sell to patients.

Balanophonin Chemical Structure

Balanophonin Chemical Structure

CAS No. : 80286-36-8

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Balanophonin Related Antibodies

Top Publications Citing Use of Products

View All COX Isoform Specific Products:

View All Isoforms
COX COX-1 COX-2 COX-3

View All TNF Receptor Isoform Specific Products:

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TNFRSF1A/CD120a TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

View All p38 MAPK Isoform Specific Products:

View All Isoforms
p38 MAPK p38α p38β MAPK13 p38δ p38γ

  • Biological Activity

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Description

Balanophonin is an anti-inflammatory and anti-cancer agent. Balanophonin inhibits microglial activation and neurodegeneration via inhibiting activated microglia-induced apoptosis[1].

IC50 & Target[1]

COX-2

 

p38

 

Cellular Effect
Cell Line Type Value Description References
BV-2 IC50
7.07 μM
Compound: 11
Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay
Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay
[PMID: 26774654]
Hep 3B2 IC50
31.5 μM
Compound: 1b
Cytotoxicity against human Hep3B cells assessed as decrease in cell viability after 48 hrs by MTT assay
Cytotoxicity against human Hep3B cells assessed as decrease in cell viability after 48 hrs by MTT assay
[PMID: 29567344]
HepG2 IC50
38.7 μM
Compound: 1b
Cytotoxicity against human HepG2 cells assessed as decrease in cell viability after 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as decrease in cell viability after 48 hrs by MTT assay
[PMID: 29567344]
In Vitro

Balanophonin (1-10 μM; 24 h) reduces Lipopolysaccharides (LPS; HY-D1056)-mediated TLR4 activation and NO production in BV2 cells[1].
Balanophonin (1-10 μM; 6 h) reduces iNOS and COX2 protein expression and TNF-α and IL-1β production in LPS-induced microglial cells[1].
Balanophonin (1-10 μM; 30 min) effectively inhibits MAPK activation[1].
Balanophonin (1-10 μM; 24 h) inhibits neuronal cell death resulting from LPS-activated microglia by regulating cleaved caspase-3 and poly ADP ribose polymerase (PARP) cleavage in N2a cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Balanophonin Related Antibodies

Western Blot Analysis[1]

Cell Line: LPS-activated BV-2 cells
Concentration: 1, 5, and 10 μM
Incubation Time: 30 min for MAPKs, 6 h for iNOS and COX2 and 24 h for PGE2, TNF-α and IL-1β
Result: Downregulated TLR4. Reduced iNOS and COX2 expression. Significantly reduced the secretion of TNF-α and IL-1β. Decreased the phosphorylation of MAPKs such as pERK, pJNK, and p-p38.

Western Blot Analysis[1]

Cell Line: Neuroblastoma N2a cells
Concentration: 1, 5, and 10 μM
Incubation Time: 24 h
Result: Slightly increased Bcl-2. Inhibited caspase-3 activation and PARP cleavage.
Molecular Weight

356.37

Formula

C20H20O6
CAS No.
SMILES

OC[C@@H]1C2=CC(/C=C/C=O)=CC(OC)=C2O[C@H]1C3=CC(OC)=C(C=C3)O
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Balanophonin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Balanophonin80286-36-8ApoptosisCOXTNF Receptorp38 MAPKCyclooxygenaseTumor Necrosis Factor ReceptorTNFRneuroinflammationneuroprotectioniNOSIL-1βBV2N2aInhibitorinhibitorinhibit

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