2. Apoptosis Immunology/Inflammation MAPK/ERK Pathway
  3. Apoptosis COX TNF Receptor p38 MAPK
  4. Balanophonin

Balanophonin is an anti-inflammatory and anti-cancer agent. Balanophonin inhibits microglial activation and neurodegeneration via inhibiting activated microglia-induced apoptosis.

For research use only. We do not sell to patients.

Balanophonin Chemical Structure

Balanophonin Chemical Structure

CAS No. : 80286-36-8

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Balanophonin Related Antibodies

Top Publications Citing Use of Products

View All COX Isoform Specific Products:

View All Isoforms
COX COX-1 COX-2 COX-3

View All TNF Receptor Isoform Specific Products:

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TNFRSF1A/CD120a TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

View All p38 MAPK Isoform Specific Products:

View All Isoforms
p38 MAPK p38α p38β MAPK13 p38δ p38γ

  • Biological Activity

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Description

Balanophonin is an anti-inflammatory and anti-cancer agent. Balanophonin inhibits microglial activation and neurodegeneration via inhibiting activated microglia-induced apoptosis[1].

IC50 & Target[1]

COX-2

 

p38

 

In Vitro

Balanophonin (1-10 μM; 24 h) reduces Lipopolysaccharides (LPS; HY-D1056)-mediated TLR4 activation and NO production in BV2 cells[1].
Balanophonin (1-10 μM; 6 h) reduces iNOS and COX2 protein expression and TNF-α and IL-1β production in LPS-induced microglial cells[1].
Balanophonin (1-10 μM; 30 min) effectively inhibits MAPK activation[1].
Balanophonin (1-10 μM; 24 h) inhibits neuronal cell death resulting from LPS-activated microglia by regulating cleaved caspase-3 and poly ADP ribose polymerase (PARP) cleavage in N2a cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Balanophonin Related Antibodies

Western Blot Analysis[1]

Cell Line: LPS-activated BV-2 cells
Concentration: 1, 5, and 10 μM
Incubation Time: 30 min for MAPKs, 6 h for iNOS and COX2 and 24 h for PGE2, TNF-α and IL-1β
Result: Downregulated TLR4. Reduced iNOS and COX2 expression. Significantly reduced the secretion of TNF-α and IL-1β. Decreased the phosphorylation of MAPKs such as pERK, pJNK, and p-p38.

Western Blot Analysis[1]

Cell Line: Neuroblastoma N2a cells
Concentration: 1, 5, and 10 μM
Incubation Time: 24 h
Result: Slightly increased Bcl-2. Inhibited caspase-3 activation and PARP cleavage.
Molecular Weight

356.37

Formula

C20H20O6
CAS No.
SMILES

OC[C@@H]1C2=CC(/C=C/C=O)=CC(OC)=C2O[C@H]1C3=CC(OC)=C(C=C3)O
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Balanophonin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Balanophonin80286-36-8ApoptosisCOXTNF Receptorp38 MAPKCyclooxygenaseTumor Necrosis Factor ReceptorTNFRneuroinflammationneuroprotectioniNOSIL-1βBV2N2aInhibitorinhibitorinhibit

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