Balhimycin

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Balhimycin is a glycopeptide antibiotic, found from the fermentation broth of a Amycolatopsis sp. Balhimycin shows anti-bacterial activity against staphylococci and anaerobes.

For research use only. We do not sell to patients.

Balhimycin Chemical Structure

CAS No. : 140932-79-2

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Description

Balhimycin is a glycopeptide antibiotic, found from the fermentation broth of a Amycolatopsis sp. Balhimycin shows anti-bacterial activity against staphylococci and anaerobes^[1].

IC₅₀ & Target

Glycopeptide

In Vitro

Balhimycin (0.39-12.5 μg/mL; 18 h) shows bactericidal activity against S. aureus, Streptococcus epidermidis, and streptococcal strains^[1].
Balhimycin (0.39-12.5 μg/mL; 18 h) shows good bactericidal activity against different Staphylococcal strains^[1].
Balhimycin (1-15 μg/mL; 30 min) leads to cell membrane scrambling of platelets, and shows stimulation of platelet apoptosis^[2]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	Staphylococcus aureus 209P, S. aureus 3066, S. aureus 20424, S. epidermidis 178, S. epidermidis 825, S. epidermidis 823, S. haemolyticus 712, S. haemolyticus 809, Streptococcus ATCC 29212, S. faecalis D 21777, S. faecalis D Endococcen, S. faecium D-59, S. faecium D-65
Concentration:	0.39-12.5 μg/mL
Incubation Time:	18 hours
Result:	Showed MIC values ranging from 0.39 μg/mL to 12.5 μg/mL against S. aureus, Streptococcus epidermidis, and streptococcal strains.

Cell Viability Assay^[1]

Cell Line:	Staphylococcus aureus 3066, S. aureus 20424, S. epidermidis 825, S. haemolyticus 712, Streptococcus faecalis ATCC29212, S. faecalis D 21777, S. faecalis D-59
Concentration:	0.39-1.56 μg/mL
Incubation Time:	18 hours
Result:	Showed MIC values ranging from 0.39 μg/mL to 1.56 μg/mL against staphylococcal strains.

Molecular Weight

1447.24

Formula

C₆₆H₇₃Cl₂N₉O₂₄

CAS No.

140932-79-2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Nadkarni SR, et al. Balhimycin, a new glycopeptide antibiotic produced by Amycolatopsis sp. Y-86,21022. Taxonomy, production, isolation and biological activity. J Antibiot (Tokyo). 1994 Mar;47(3):334-41. [Content Brief]

[2]. Towhid ST, et al. Stimulation of platelet apoptosis by balhimycin. Biochem Biophys Res Commun. 2013 May 31;435(2):323-6. [Content Brief]

Balhimycin Related Classifications

Infection

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Balhimycin140932-79-2AntibioticBacterialanti-bacterial activitystaphylococcianaerobesInhibitorinhibitorinhibit

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