BAPTA tetrasodium

Name: BAPTA tetrasodium
Brand: MedChemExpress
SKU: HY-100168A
Rating: 5.0 (25 reviews)

Cat. No.: HY-100168A Purity: 99.70%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

BAPTA tetrasodium is a selective chelator for calcium. BAPTA tetrasodium, as calcium indicator, has high selectivity against magnesium and calcium. BAPTA tetrasodium is widely used as an intracellular buffer for investigating the effects of Ca²⁺ release from intracellular stores or influx via Ca²⁺-permeable channels in the plasma membrane. BAPTA tetrasodium can also inhibit phospholipase C activity independently of their role as Ca²⁺ chelators.

For research use only. We do not sell to patients.

BAPTA tetrasodium Chemical Structure

CAS No. : 126824-24-6

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	USD 50	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	USD 50	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 40	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 25 publication(s) in Google Scholar

Other Forms of BAPTA tetrasodium:

BAPTA In-stock
BAPTA tetrapotassium Get quote

25 Publications Citing Use of MCE BAPTA tetrasodium

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Phospholipase A PLD Phospholipase C

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

BAPTA (0.3-30 μM; 1 h) can be used for the prevention of [Ca²⁺]-induced cell damage, but disturbe calcium signalling in isingle differentiated NH15-CA2 neuroblastoma and glioma hybrid cells^[3].
BAPTA (0-10 mM) inhibits phospholipase C (PLC) activity in a dose-dependent manner, and is unrelated to Ca²⁺^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

564.36

Formula

C₂₂H₂₀N₂Na₄O₁₀

CAS No.

126824-24-6

Appearance

Solid

Color

White to off-white

SMILES

O=C(O[Na])CN(C1=CC=CC=C1OCCOC2=CC=CC=C2N(CC(O[Na])=O)CC(O[Na])=O)CC(O[Na])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (177.19 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7719 mL	8.8596 mL	17.7192 mL
5 mM	0.3544 mL	1.7719 mL	3.5438 mL
10 mM	0.1772 mL	0.8860 mL	1.7719 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.70%

Select Batch:

Data Sheet (275 KB) SDS (393 KB)

COA (251 KB) HNMR (283 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

References

[1]. R Y Tsien, et al. New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures. Biochemistry. 1980 May 27;19(11):2396-404. [Content Brief]

[2]. Roger C Hardie, et al. Inhibition of phospholipase C activity in Drosophila photoreceptors by 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid (BAPTA) and di-bromo BAPTA. Cell Calcium. 2005 Dec;38(6):547-56. [Content Brief]

[3]. M B Collatz, et al. Intracellular calcium chelator BAPTA protects cells against toxic calcium overload but also alters physiological calcium responses. Cell Calcium [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	1.7719 mL	8.8596 mL	17.7192 mL	44.2980 mL
	5 mM	0.3544 mL	1.7719 mL	3.5438 mL	8.8596 mL
	10 mM	0.1772 mL	0.8860 mL	1.7719 mL	4.4298 mL
	15 mM	0.1181 mL	0.5906 mL	1.1813 mL	2.9532 mL
	20 mM	0.0886 mL	0.4430 mL	0.8860 mL	2.2149 mL
	25 mM	0.0709 mL	0.3544 mL	0.7088 mL	1.7719 mL
	30 mM	0.0591 mL	0.2953 mL	0.5906 mL	1.4766 mL
	40 mM	0.0443 mL	0.2215 mL	0.4430 mL	1.1074 mL
	50 mM	0.0354 mL	0.1772 mL	0.3544 mL	0.8860 mL
	60 mM	0.0295 mL	0.1477 mL	0.2953 mL	0.7383 mL
	80 mM	0.0221 mL	0.1107 mL	0.2215 mL	0.5537 mL
	100 mM	0.0177 mL	0.0886 mL	0.1772 mL	0.4430 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.