2. Metabolic Enzyme/Protease
  3. MMP
  4. BAY-7598

BAY-7598 is a potent, orally bioavailable, and selective MMP12 inhibitor probe with IC50s of 0.085, 0.67 and 1.1 nM for human MMP12, murine MMP12, and rat MMP12, respectively.

For research use only. We do not sell to patients.

BAY-7598 Chemical Structure

BAY-7598 Chemical Structure

CAS No. : 1816257-74-5

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BAY-7598 Related Antibodies

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MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8

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Description

BAY-7598 is a potent, orally bioavailable, and selective MMP12 inhibitor probe with IC50s of 0.085, 0.67 and 1.1 nM for human MMP12, murine MMP12, and rat MMP12, respectively[1].

IC50 & Target

IC50: 0.085 nM (human MMP12), 0.67 nM (murine MMP12), 1.1 nM (rat MMP12)[1]
In Vitro

BAY-7598 inhibits human MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP13, MMP14, and MMP16 with IC50s of 44, 360, 600, 15, 460, 12, 67, 250, and 940 nM, respectively[1].
BAY-7598 inhibits murine MMP2, MMP3, MMP7, MMP8, and MMP9 with IC50s of 45, 270, 130, 54, and 210 nM, respectively[1].
BAY-7598 inhibits rat MMP2, MMP8, and MMP9 with IC50s of 45, 67, and 1000 nM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BAY-7598 Related Antibodies
In Vivo

BAY-7598 has moderate terminal elimination half-life (t1/2=4.6 h and 4.1 h for mouse (0.3 mg/kg, iv), mouse (5.0 mg/kg, p.o.) , respectively)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mouse[1]
Dosage: 0.3 mg/kg (i.v.) and 5.0 mg/kg (p.o.)
Administration: Administered i.v. (0.3 mg/kg) and p.o. (5.0 mg/kg) (Pharmacokinetic Analysis)
Result: T1/2=4.6 h and 4.1 h for 0.3 mg/kg (i.v.) and 5.0 mg/kg (p.o.), respectively.
Molecular Weight

505.56

Formula

C28H31N3O6
CAS No.
SMILES

O=C([C@H]1[C@H](CN2N=NC3=CC=CC=C3C2=O)CC[C@@H]1C(C4=CC=C(OCCC5CCOCC5)C=C4)=O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BAY-7598 Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BAY-75981816257-74-5BAY7598BAY 7598MMPMatrix metalloproteinasesBAY-7598 is a potentorally bioavailableand selective MMP12 inhibitor probe with IC50s of 0.0850.67 and 1.1 nM for human MMP12murine MMP12and rat MMP12respectively. Anti-inflammation activity[1].Inhibitorinhibitorinhibit

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