2. GPCR/G Protein
  3. Leukotriene Receptor
  4. BAY-u 9773

BAY-u 9773 is a non-selective antagonist of the CysLT receptors (cysteinyl leukotrienes receptors) with about the same IC50 for CysLT1 and CysLT2. BAY-u9773 is used for the inhibition of LT responses.

For research use only. We do not sell to patients.

BAY-u 9773 Chemical Structure

BAY-u 9773 Chemical Structure

CAS No. : 154978-38-8

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Based on 1 publication(s) in Google Scholar

BAY-u 9773 Related Antibodies

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1 Publications Citing Use of MCE BAY-u 9773

View All Leukotriene Receptor Isoform Specific Products:

View All Isoforms
LTB4 LTC4/CysLT2 LTD4/CysLT1 LTE4

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Description

BAY-u 9773 is a non-selective antagonist of the CysLT receptors (cysteinyl leukotrienes receptors) with about the same IC50 for CysLT1 and CysLT2. BAY-u9773 is used for the inhibition of LT responses[1].

IC50 & Target

LTD4

 

LTC4

 

Cellular Effect
Cell Line Type Value Description References
CHO IC50
0.44 μM
Compound: BAY-u9773
Antagonist activity at human CysLT1 receptor expressed in CHO cells assessed as inhibition of LTD4-inudced intracellular calcium influx preincubated for 30 mins before LTD4 addition by Fura2-AM assay
Antagonist activity at human CysLT1 receptor expressed in CHO cells assessed as inhibition of LTD4-inudced intracellular calcium influx preincubated for 30 mins before LTD4 addition by Fura2-AM assay
[PMID: 25408836]
HEK293 IC50
0.3 μM
Compound: BAY-u9773
Antagonist activity at human CysLT2 receptor expressed in HEK293 cells assessed as inhibition of LTD4-inudced intracellular calcium influx preincubated for 30 mins before LTD4 addition by Fura2-AM assay
Antagonist activity at human CysLT2 receptor expressed in HEK293 cells assessed as inhibition of LTD4-inudced intracellular calcium influx preincubated for 30 mins before LTD4 addition by Fura2-AM assay
[PMID: 25408836]
Molecular Weight

472.64

Formula

C27H36O5S
CAS No.
SMILES

OC(CCC[C@H](O)[C@@H](/C=C/C=C/C=C\C/C=C\CCCCC)SC1=CC=C(C=C1)C(O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BAY-u 9773 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BAY-u 9773154978-38-8Leukotriene ReceptorInhibitorinhibitorinhibit

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BAY-u 9773
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HY-107609
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