1. Vitamin D Related/Nuclear Receptor
  2. Estrogen Receptor/ERR
  3. Bazedoxifene-d4 acetate

Bazedoxifene-d4 acetate  (Synonyms: TSE-424-d4 acetate)

Cat. No.: HY-A0031S2
Handling Instructions

Bazedoxifene-d4 (acetate) is the deuterium labeled Bazedoxifene[1]. Bazedoxifene (TSE-424) is an oral, BBB-penetrant nonsteroidal selective estrogen receptor modulator (SERM), with IC50s of 23 nM and 99 nM for ERα and ERβ, respectively. Bazedoxifene can be used for the research of osteoporosis. Bazedoxifene also acts as an inhibitor of IL-6/GP130 protein-protein interactions and can be used for the research of pancreatic cancer[2][3].

For research use only. We do not sell to patients.

Bazedoxifene-d<sub>4</sub> acetate Chemical Structure

Bazedoxifene-d4 acetate Chemical Structure

CAS No. : 1795027-71-2

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Description

Bazedoxifene-d4 (acetate) is the deuterium labeled Bazedoxifene[1]. Bazedoxifene (TSE-424) is an oral, BBB-penetrant nonsteroidal selective estrogen receptor modulator (SERM), with IC50s of 23 nM and 99 nM for ERα and ERβ, respectively. Bazedoxifene can be used for the research of osteoporosis. Bazedoxifene also acts as an inhibitor of IL-6/GP130 protein-protein interactions and can be used for the research of pancreatic cancer[2][3].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

534.68

Formula

C32H34D4N2O5

CAS No.
Unlabeled CAS

198481-32-2

SMILES

CC(O)=O.CC(C1=CC(O)=CC=C12)=C(C3=CC=C(C=C3)O)N2CC4=CC=C(C=C4)OC([2H])([2H])C([2H])([2H])N5CCCCCC5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Bazedoxifene-d4 acetate
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HY-A0031S2
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