BBMP  (Synonyms: 5-(Benzylsulfonyl)-4-bromo-2-methyl-3(2H)-pyridazinone)

BBMP is a permeability transition pore (PTP) inhibitor. BBMP prevents Ca²⁺-induced permeability transition and mitochondrial depolarization. BBMP possess potential for the neurodegenerative disorders research^[1].

BBMP is effective in both swelling and membrane potential assays displaying pIC₅₀ values of 5.5 and 5.6, respectively. BBMP dose-dependently prevents DNA fragmentation induced by KCl 25/5 mM shift and serum deprivation in cerebellar granule neurons with a pIC₅₀ of 5.7. The inhibition of PTP-mediated cytochrome c release observed in isolated mitochondria at 10 and 100 μM may explain its neuroprotective properties in vitro^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

343.20

C₁₂H₁₁BrN₂O₃S

97120-13-3

O=C1C(Br)=C(S(=O)(CC2=CC=CC=C2)=O)C=NN1C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Bruno Fuks, et al. In vitro properties of 5-(benzylsulfonyl)-4-bromo-2-methyl-3(2H)-pyridazinone: a novel permeability transition pore inhibitor. Eur J Pharmacol. 2005 Sep 5;519(1-2):24-30.  [Content Brief]