Bcl-2-IN-11 

Bcl-2-IN-11 (compound 6) is a potent and selective Bcl-2 activity inhibitor, with an IC₅₀ of 0.9 nM. Bcl-2-IN-11 shows weak inhibition of Bcl-xl (IC₅₀ > 1000 nM). Bcl-2-IN-11 can be used for the research of a variety of cancers caused by abnormal overexpression of Bcl-2 family proteins: especially malignant hematologic diseases of acute lymphoid leukemia, etc. Bcl-2-IN-11 can also avoid toxic side effects caused by Bcl-xl inhibition, such as thrombocytopenia^[1].

Bcl-2-IN-11 (compound 6) inhibits the proliferation of RS4;11 acute lymphocyte cells, with an IC₅₀ of 2.37 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

902.43

C₄₅H₄₉ClFN₇O₈S

2760536-88-5

O=S(NC(C(C=CC(N1C[C@H](N(CC1)CC2=C(C3=CC=C(C=C3)Cl)CC(C)(CC2)C)C)=C4)=C4OC5=CN=C(NC=C6)C6=C5)=O)(C7=CC([N+]([O-])=O)=C(C(F)=C7)NC[C@H]8COCCO8)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Kong Xianglong, et al. Heterocyclic compound as bcl-2 inhibitor. WO2022028353A1.