2. Apoptosis NF-κB Metabolic Enzyme/Protease Immunology/Inflammation
  3. Bcl-2 Family Apoptosis Reactive Oxygen Species
  4. Bcl-2-IN-20

Bcl-2-IN-20 (Compound 81) is an inhibitor for Bcl-2 with IC50 <10 μM (79.1% inhibition at 9 μM). Bcl-2-IN-20 exhibits cytotoxicity in SK-MEL-28 (IC50>10 μM), A549 (IC50=6.1 μM), HepG2 (IC50>10 μM), MCF-7 (IC50=8.9 μM), HCT116 (IC50>10 μM) and HEK-293 (IC50=14.1 μM). Bcl-2-IN-20 promotes the ROS production, induces apoptosis and DNA damage.

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Bcl-2-IN-20 Chemical Structure

Bcl-2-IN-20 Chemical Structure

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Bcl-2-IN-20 Related Antibodies

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Description

Bcl-2-IN-20 (Compound 81) is an inhibitor for Bcl-2 with IC50 <10 μM (79.1% inhibition at 9 μM). Bcl-2-IN-20 exhibits cytotoxicity in SK-MEL-28 (IC50>10 μM), A549 (IC50=6.1 μM), HepG2 (IC50>10 μM), MCF-7 (IC50=8.9 μM), HCT116 (IC50>10 μM) and HEK-293 (IC50=14.1 μM). Bcl-2-IN-20 promotes the ROS production, induces apoptosis and DNA damage[1].

Molecular Weight

500.32

Formula

C22H14BrNO6S
SMILES

O=C(/C(S1)=C/C2=COC3=CC=C(Br)C=C3C2=O)N(CC(C4=CC=C(OC)C=C4)=O)C1=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Bcl-2-IN-20 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bcl-2-IN-20Bcl-2 FamilyApoptosisReactive Oxygen SpeciesSK-MEL-28A549HepG2MCF-7HCT116HEK-293Inhibitorinhibitorinhibit

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