2. Apoptosis
  3. Bcl-2 Family
  4. Bcl-2-IN-4

Bcl-2-IN-4 is a potent, orally active and selective Bcl-2 inhibitor with an IC50 of 1.5 nM. Bcl-2-IN-4 displays >200-fold selectivity over Bcl-xL (IC50 of 411 nM). Bcl-2-IN-4 inhibits RS4; 11 cell proliferation with an IC50 of 2.7 nM (WO2021180040A1; compound 2).

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Bcl-2-IN-4 Chemical Structure

Bcl-2-IN-4 Chemical Structure

CAS No. : 2703134-40-9

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Bcl-2-IN-4 Related Antibodies

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Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

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Description

Bcl-2-IN-4 is a potent, orally active and selective Bcl-2 inhibitor with an IC50 of 1.5 nM. Bcl-2-IN-4 displays >200-fold selectivity over Bcl-xL (IC50 of 411 nM). Bcl-2-IN-4 inhibits RS4; 11 cell proliferation with an IC50 of 2.7 nM (WO2021180040A1; compound 2)[1].

IC50 & Target[1]

Bcl-2

1.5 nM (IC50)

Bcl-xL

411 nM (IC50)

Molecular Weight

908.46

Formula

C46H50ClN9O7S
CAS No.
SMILES

O=C(NS(=O)(C1=C2C(N=CN2)=C(NCC3CCOCC3)C([N+]([O-])=O)=C1)=O)C4=CC=C(N5CCN(CC6=C(C7=CC=C(Cl)C=C7)CC(C)(C)CC6)CC5)C=C4OC8=CN=C(NC=C9)C9=C8
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Bcl-2-IN-4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bcl-2-IN-42703134-40-9Bcl-2 FamilyBCL-2 inhibitororally activeanticancer effectInhibitorinhibitorinhibit

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