Bcl-2-IN-7

Cat. No.: HY-144792: FAQs
Data Sheet Handling Instructions

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Bcl-2-IN-7 (compound 6) is a potent Bcl-2 (B-cell lymphoma-2) inhibitor. Bcl-2-IN-7 down-regulates the expression of Bcl-2, and increases the expression of p53, Bax, and caspase-7 mRNA. Bcl-2-IN-7 induces cell cycle arrest and apoptosis in breast cancer MCF-7 cells. Bcl-2-IN-7 shows good anticancer activity, with IC₅₀ values of 20.17, 22.64, 45.57, and 51.50 μM against MCF-7, LoVo, HepG2, and A549 cell lines, respectively.

For research use only. We do not sell to patients.

Bcl-2-IN-7 Chemical Structure

CAS No. : 3027734-46-6

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Purity & Documentation
References
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Description

IC₅₀ & Target

Bcl-2

Bax

Caspase-7

Molecular Weight

510.59

Formula

C₂₄H₂₂N₄O₅S₂

CAS No.

3027734-46-6

SMILES

O=C(NC1=CC=CC=C1C)CSC(N2C3=CC=C(S(=O)(N)=O)C=C3)=NC4=C(C=CC=C4OC)C2=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Alqahtani AS, et al. Novel sulphonamide-bearing methoxyquinazolinone derivatives as anticancer and apoptosis inducers: synthesis, biological evaluation and in silico studies. J Enzyme Inhib Med Chem. 2022 Dec;37(1):86-99. [Content Brief]

Bcl-2-IN-7 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bcl-2-IN-73027734-46-6Bcl-2 FamilyMDM-2/p53CaspaseApoptosisbreast cancerMCF-7 cellsB-cell lymphoma-2 (Bcl-2)quinazolinoneapoptosisbenzenesulfonamidecaspasecytotoxicityInhibitorinhibitorinhibit

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