2. Apoptosis
  3. Bcl-2 Family MDM-2/p53 Caspase Apoptosis
  4. Bcl-2-IN-7

Bcl-2-IN-7 (compound 6) is a potent Bcl-2 (B-cell lymphoma-2) inhibitor. Bcl-2-IN-7 down-regulates the expression of Bcl-2, and increases the expression of p53, Bax, and caspase-7 mRNA. Bcl-2-IN-7 induces cell cycle arrest and apoptosis in breast cancer MCF-7 cells. Bcl-2-IN-7 shows good anticancer activity, with IC50 values of 20.17, 22.64, 45.57, and 51.50 μM against MCF-7, LoVo, HepG2, and A549 cell lines, respectively.

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Bcl-2-IN-7 Chemical Structure

Bcl-2-IN-7 Chemical Structure

CAS No. : 3027734-46-6

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Bcl-2-IN-7 Related Antibodies

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

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Description

Bcl-2-IN-7 (compound 6) is a potent Bcl-2 (B-cell lymphoma-2) inhibitor. Bcl-2-IN-7 down-regulates the expression of Bcl-2, and increases the expression of p53, Bax, and caspase-7 mRNA. Bcl-2-IN-7 induces cell cycle arrest and apoptosis in breast cancer MCF-7 cells. Bcl-2-IN-7 shows good anticancer activity, with IC50 values of 20.17, 22.64, 45.57, and 51.50 μM against MCF-7, LoVo, HepG2, and A549 cell lines, respectively[1].

IC50 & Target

Bcl-2

 

Bax

 

Caspase-7

 

Molecular Weight

510.59

Formula

C24H22N4O5S2
CAS No.
SMILES

O=C(NC1=CC=CC=C1C)CSC(N2C3=CC=C(S(=O)(N)=O)C=C3)=NC4=C(C=CC=C4OC)C2=O
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
References
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Bcl-2-IN-7 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bcl-2-IN-73027734-46-6Bcl-2 FamilyMDM-2/p53CaspaseApoptosisbreast cancerMCF-7 cellsB-cell lymphoma-2 (Bcl-2)quinazolinoneapoptosisbenzenesulfonamidecaspasecytotoxicityInhibitorinhibitorinhibit

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