2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. BCN-endo-PEG4-NHS

BCN-endo-PEG4-NHS is an ADC Linker containing 4 PEG units. BCN-endo-PEG4-NHS contains the lyophilic bidentate macrocyclic ligand endo-BCN, which allows for further synthesis of macrocyclic complexes. In click chemistry, endo-BCN can react with molecules containing azide groups to form stable triazoles in the absence of catalysts.

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BCN-endo-PEG4-NHS Chemical Structure

BCN-endo-PEG4-NHS Chemical Structure

CAS No. : 1702356-19-1

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BCN-endo-PEG4-NHS Related Antibodies

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Description

BCN-endo-PEG4-NHS is an ADC Linker containing 4 PEG units. BCN-endo-PEG4-NHS contains the lyophilic bidentate macrocyclic ligand endo-BCN, which allows for further synthesis of macrocyclic complexes. In click chemistry, endo-BCN can react with molecules containing azide groups to form stable triazoles in the absence of catalysts.

Molecular Weight

538.59

Formula

C26H38N2O10
CAS No.
Appearance

Viscous Liquid

Color

Colorless to light yellow

SMILES

O=C(CCC1=O)N1OC(CCOCCOCCOCCOCCNC(OC[C@@H]2[C@@]3([H])[C@]2([H])CCC#CCC3)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (371.34 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8567 mL 9.2835 mL 18.5670 mL
5 mM 0.3713 mL 1.8567 mL 3.7134 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥97.0%

SDS (393 KB)

COA (243 KB) HNMR (136 KB) MS (108 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8567 mL 9.2835 mL 18.5670 mL 46.4175 mL
5 mM 0.3713 mL 1.8567 mL 3.7134 mL 9.2835 mL
10 mM 0.1857 mL 0.9283 mL 1.8567 mL 4.6417 mL
15 mM 0.1238 mL 0.6189 mL 1.2378 mL 3.0945 mL
20 mM 0.0928 mL 0.4642 mL 0.9283 mL 2.3209 mL
25 mM 0.0743 mL 0.3713 mL 0.7427 mL 1.8567 mL
30 mM 0.0619 mL 0.3094 mL 0.6189 mL 1.5472 mL
40 mM 0.0464 mL 0.2321 mL 0.4642 mL 1.1604 mL
50 mM 0.0371 mL 0.1857 mL 0.3713 mL 0.9283 mL
60 mM 0.0309 mL 0.1547 mL 0.3094 mL 0.7736 mL
80 mM 0.0232 mL 0.1160 mL 0.2321 mL 0.5802 mL
100 mM 0.0186 mL 0.0928 mL 0.1857 mL 0.4642 mL
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BCN-endo-PEG4-NHS Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BCN-endo-PEG4-NHS1702356-19-1ADC LinkerAntibody-drug conjugates linkerClick ChemicalsPEG LinkerInhibitorinhibitorinhibit

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