1. PROTAC
  2. PROTAC Linkers
  3. BCN-​exo-​PEG3-​NH2

BCN- exo- PEG3- NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. BCN- exo- PEG3- NH2 is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

For research use only. We do not sell to patients.

BCN-​exo-​PEG3-​NH2 Chemical Structure

BCN-​exo-​PEG3-​NH2 Chemical Structure

CAS No. : 1841134-72-2

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Description

BCN- exo- PEG3- NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. BCN- exo- PEG3- NH2 is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

368.47

Formula

C19H32N2O5

CAS No.
Appearance

Liquid (Density: 1.14±0.1 g/cm3)

Color

Colorless to light yellow

SMILES

NCCOCCOCCOCCNC(OC[C@@H]1[C@@]2([H])CCC#CCC[C@@]12[H])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Pure form -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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BCN-​exo-​PEG3-​NH2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
BCN-​exo-​PEG3-​NH2
Cat. No.:
HY-133402
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