1. Membrane Transporter/Ion Channel
  2. BCRP
  3. BCRP-IN-1

BCRP-IN-1 (compound 48) is a potent inhibitor of breast cancer resistance protein (BCRP), with IC50s of 2.92 μM and 2.46 μM in Hoechst 33342 assay and Pheophorbide A assay, respectively.

For research use only. We do not sell to patients.

BCRP-IN-1 Chemical Structure

BCRP-IN-1 Chemical Structure

CAS No. : 765899-28-3

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Description

BCRP-IN-1 (compound 48) is a potent inhibitor of breast cancer resistance protein (BCRP), with IC50s of 2.92 μM and 2.46 μM in Hoechst 33342 assay and Pheophorbide A assay, respectively[1].

Cellular Effect
Cell Line Type Value Description References
MDCK-II IC50
2.46 μM
Compound: 48
Inhibition of human BCRP expressed in MDCK2 cells assessed as pheophorbide A accumulation treated 30 mins before pheophorbide A addition measured up to 120 mins by flow cytometry
Inhibition of human BCRP expressed in MDCK2 cells assessed as pheophorbide A accumulation treated 30 mins before pheophorbide A addition measured up to 120 mins by flow cytometry
[PMID: 24184213]
MDCK-II IC50
2.92 μM
Compound: 48
Inhibition of human BCRP expressed in MDCK2 cells assessed as Hoechst 33342 accumulation treated 30 mins before Hoechst 33342 addition measured up to 120 mins by fluorescence assay
Inhibition of human BCRP expressed in MDCK2 cells assessed as Hoechst 33342 accumulation treated 30 mins before Hoechst 33342 addition measured up to 120 mins by fluorescence assay
[PMID: 24184213]
Molecular Weight

326.31

Formula

C16H14N4O4

CAS No.
SMILES

O=[N+](C1=CC=C(NC2=C3C=C(OC)C(OC)=CC3=NC=N2)C=C1)[O-]

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BCRP-IN-1
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HY-129037
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