2. Apoptosis
  3. Bcl-2 Family
  4. BDA-366

BDA-366 is a potent Bcl2 antagonist (Ki = 3.3 nM), binding Bcl2-BH4 domain with high affinity and selectivity. BDA-366 induces conformational change in Bcl2 that abrogates its antiapoptotic function, converting it from a survival molecule to a cell death inducer. BDA-366 suppresses growth of lung cancer cells.

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BDA-366 Chemical Structure

BDA-366 Chemical Structure

CAS No. : 1909226-00-1

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Based on 1 publication(s) in Google Scholar

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Description

BDA-366 is a potent Bcl2 antagonist (Ki = 3.3 nM), binding Bcl2-BH4 domain with high affinity and selectivity. BDA-366 induces conformational change in Bcl2 that abrogates its antiapoptotic function, converting it from a survival molecule to a cell death inducer. BDA-366 suppresses growth of lung cancer cells[1].

IC50 & Target[1]

Bcl-2

3.3 nM (Ki)

Molecular Weight

423.50

Formula

C24H29N3O4
CAS No.
SMILES

O=C1C2=C(C(NC[C@H]3CO3)=CC=C2NC[C@H](O)CN(CC)CC)C(C4=CC=CC=C41)=O
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Purity & Documentation
References
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BDA-366 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BDA-3661909226-00-1BDA366BDA 366Bcl-2 FamilyAnticancerAntitumorLung cancerBcl2-BH4 domainAntiapoptotic functionInhibitorinhibitorinhibit

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