BDCRB (Synonyms: 2-Bromo-5,6-dichloro-1-β-D-ribofuranosyl benzimidazole)

Cat. No.: HY-19296: FAQs
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BDCRB is a selective Human cytomegalovirus (HCMV) inhibitor through blocking the maturational cleavage of high-molecular-weight DNA. BDCRB shows a mean IC₅₀ of 0.03 μM for viral yield at 72 h postinfection.

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BDCRB Chemical Structure

CAS No. : 142356-43-2

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Biological Activity
Purity & Documentation
References
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
BSC-1	IC₅₀	130 μM Compound: BDCRB (table-1)	Inhibitory concentration required against herpes simplex virus type-1 (HSV-1) expressed in BSC-1 cells was determined by ELISA assay Inhibitory concentration required against herpes simplex virus type-1 (HSV-1) expressed in BSC-1 cells was determined by ELISA assay	[PMID: 15509176]
BSC-1	IC₅₀	130 μM Compound: BDCRB (table-1)	Inhibitory concentration required against herpes simplex virus type-1 (HSV-1) expressed in BSC-1 cells was determined by ELISA assay Inhibitory concentration required against herpes simplex virus type-1 (HSV-1) expressed in BSC-1 cells was determined by ELISA assay	[PMID: 15509175]
BSC-1	IC₅₀	130 μM Compound: BDCRB (table-1)	Inhibitory concentration required against herpes simplex virus type-1 (HSV-1) expressed in BSC-1 cells was determined by ELISA assay Inhibitory concentration required against herpes simplex virus type-1 (HSV-1) expressed in BSC-1 cells was determined by ELISA assay	[PMID: 15509174]
HFF	IC₅₀	0.3 μM Compound: 4b	Compound was tested for antiviral activity against wild-type Towne virus of HCMV in yield reduction assay using HFF cells Compound was tested for antiviral activity against wild-type Towne virus of HCMV in yield reduction assay using HFF cells	[PMID: 10882374]
HFF	IC₅₀	0.34 μM Compound: 4b	Compound was tested for antiviral activity against wild-type AD169 virus of HCMV in plaque reduction assay using HFF cells Compound was tested for antiviral activity against wild-type AD169 virus of HCMV in plaque reduction assay using HFF cells	[PMID: 10882374]
HFF	IC₅₀	0.41 μM Compound: 4b	Compound was tested for antiviral activity against 2916 strain of HCMV in plaque reduction assay using HFF cells Compound was tested for antiviral activity against 2916 strain of HCMV in plaque reduction assay using HFF cells	[PMID: 10882374]
HFF	IC₅₀	0.7 μM Compound: 4b	Compound was tested for antiviral activity against Towne strain of HCMV in a plaque reduction assay using HFF cells Compound was tested for antiviral activity against Towne strain of HCMV in a plaque reduction assay using HFF cells	[PMID: 10882374]
HFF	IC₅₀	0.7 μM Compound: BDCRB (table-1)	Inhibitory concentration required against human cytomegalovirus (HCMV) expressed in HFF cells was determined by plaque reduction assay Inhibitory concentration required against human cytomegalovirus (HCMV) expressed in HFF cells was determined by plaque reduction assay	[PMID: 15509176]
HFF	IC₅₀	0.7 μM Compound: BDCRB (table-1)	Inhibitory concentration required against human cytomegalovirus (HCMV) expressed in HFF cells was determined by plaque reduction assay Inhibitory concentration required against human cytomegalovirus (HCMV) expressed in HFF cells was determined by plaque reduction assay	[PMID: 15509175]
HFF	IC₅₀	0.7 μM Compound: BDCRB (table-1)	Inhibitory concentration required against human cytomegalovirus (HCMV) expressed in HFF cells was determined by plaque reduction assay Inhibitory concentration required against human cytomegalovirus (HCMV) expressed in HFF cells was determined by plaque reduction assay	[PMID: 15509174]
HFF	IC₅₀	0.7 μM Compound: 5	Compound was tested for antiviral activity against human cytomegalovirus (HCMV) by plaque reduction assay using HFF cells Compound was tested for antiviral activity against human cytomegalovirus (HCMV) by plaque reduction assay using HFF cells	[PMID: 10882375]
HFF	IC₅₀	0.99 μM Compound: BDCRB (table-1)	Inhibitory concentration required against human cytomegalovirus (HCMV) wild type expressed in HFF cells was determined by plaque reduction assay Inhibitory concentration required against human cytomegalovirus (HCMV) wild type expressed in HFF cells was determined by plaque reduction assay	[PMID: 15509176]
HFF	IC₅₀	1.7 μM Compound: 4b	Compound was tested for antiviral activity against wild-type Towne virus of HCMV in plaque reduction assay using HFF cells Compound was tested for antiviral activity against wild-type Towne virus of HCMV in plaque reduction assay using HFF cells	[PMID: 10882374]
HFF	IC₅₀	118 μM Compound: BDCRB (table-1)	Cytotoxicity produced in stationary HFF cells was determined by microscopic inspection of uninfected cells Cytotoxicity produced in stationary HFF cells was determined by microscopic inspection of uninfected cells	[PMID: 15509176]
HFF	IC₅₀	118 μM Compound: BDCRB (table-1)	Cytotoxicity produced in stationary HFF cells was determined by microscopic inspection of uninfected cells Cytotoxicity produced in stationary HFF cells was determined by microscopic inspection of uninfected cells	[PMID: 15509175]
HFF	IC₅₀	118 μM Compound: BDCRB (table-1)	Cytotoxicity produced in stationary HFF cells was determined by microscopic inspection of uninfected cells Cytotoxicity produced in stationary HFF cells was determined by microscopic inspection of uninfected cells	[PMID: 15509174]
HFF	IC₅₀	118 μM Compound: 1b (BDCRB)	Concentration required to inhibit stationary human HFF cell line growth was determined by microscopy examination Concentration required to inhibit stationary human HFF cell line growth was determined by microscopy examination	[PMID: 15509173]
HFF	IC₅₀	118 μM Compound: 4b	Compound was tested for visual cytotoxicity on HFF cells unaffected by HCMV at the time of plaque enumeration Compound was tested for visual cytotoxicity on HFF cells unaffected by HCMV at the time of plaque enumeration	[PMID: 10882374]
HFF	IC₅₀	12 μM Compound: BDCRB (table-1)	Inhibitory concentration required against human cytomegalovirus (HCMV) D10 strain (UL89 mutant gene) expressed in HFF cells was determined by plaque reduction assay Inhibitory concentration required against human cytomegalovirus (HCMV) D10 strain (UL89 mutant gene) expressed in HFF cells was determined by plaque reduction assay	[PMID: 15509176]
HFF	IC₅₀	29 μM Compound: BDCRB (table-1)	Inhibitory concentration required against human cytomegalovirus (HCMV) C4 strain (UL56 + UL89 mutant gene) expressed in HFF cells was determined by plaque reduction assay Inhibitory concentration required against human cytomegalovirus (HCMV) C4 strain (UL56 + UL89 mutant gene) expressed in HFF cells was determined by plaque reduction assay	[PMID: 15509176]
HFF	IC₅₀	31 μM Compound: 4b	Compound was tested for antiviral activity against C-4 Towne virus of HCMV in plaque reduction assay using HFF cells Compound was tested for antiviral activity against C-4 Towne virus of HCMV in plaque reduction assay using HFF cells	[PMID: 10882374]
HFF	CC₅₀	313.6 μM Compound: BDCRB	Cytotoxicity against HFF after 8 days by XTT assay Cytotoxicity against HFF after 8 days by XTT assay	[PMID: 19786605]
HFF	IC₅₀	6.7 μM Compound: BDCRB (table-1)	Inhibitory concentration required against human cytomegalovirus (HCMV) r56 strain (UL56 mutant gene) expressed in HFF cells was determined by plaque reduction assay Inhibitory concentration required against human cytomegalovirus (HCMV) r56 strain (UL56 mutant gene) expressed in HFF cells was determined by plaque reduction assay	[PMID: 15509176]
HFF	IC₅₀	8 μM Compound: 4b	Compound was tested for antiviral activity against C-4 Towne virus of HCMV in yield reduction assay using HFF cells Compound was tested for antiviral activity against C-4 Towne virus of HCMV in yield reduction assay using HFF cells	[PMID: 10882374]
KB	IC₅₀	> 100 μM Compound: BDCRB (table-1)	Cytotoxicity against KB cells was determined by crystal violet staining and spectrophotometric quantitation of dye eluted from stained cells Cytotoxicity against KB cells was determined by crystal violet staining and spectrophotometric quantitation of dye eluted from stained cells	[PMID: 15509176]
KB	IC₅₀	> 100 μM Compound: BDCRB (table-1)	Cytotoxicity against KB cells was determined by crystal violet staining and spectrophotometric quantitation of dye eluted from stained cells Cytotoxicity against KB cells was determined by crystal violet staining and spectrophotometric quantitation of dye eluted from stained cells	[PMID: 15509175]
KB	IC₅₀	> 100 μM Compound: BDCRB (table-1)	Cytotoxicity against KB cells was determined by crystal violet staining and spectrophotometric quantitation of dye eluted from stained cells Cytotoxicity against KB cells was determined by crystal violet staining and spectrophotometric quantitation of dye eluted from stained cells	[PMID: 15509174]
KB	IC₅₀	> 100 μM Compound: 1b (BDCRB)	Concentration required to inhibit KB cell line growth was determined by crystal violet staining method Concentration required to inhibit KB cell line growth was determined by crystal violet staining method	[PMID: 15509173]
NIH3T3	CC₅₀	88.1 μM Compound: BDCRB	Cytotoxicity against mouse NIH/3T3 cells after 8 days by XTT assay Cytotoxicity against mouse NIH/3T3 cells after 8 days by XTT assay	[PMID: 19786605]

Molecular Weight

398.04

Formula

C₁₂H₁₁BrCl₂N₂O₄

CAS No.

142356-43-2

SMILES

O[C@H]1[C@H](N2C3=CC(Cl)=C(Cl)C=C3N=C2Br)O[C@H](CO)[C@H]1O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Biron KK, et al. Potent and selective inhibition of human cytomegalovirus replication by 1263W94, a benzimidazole L-riboside with a unique mode of action. Antimicrob Agents Chemother. 2002 Aug;46(8):2365-72. [Content Brief]

BDCRB Related Classifications

Infection

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BDCRB142356-43-22-Bromo-5,6-dichloro-1-β-D-ribofuranosyl benzimidazoleOthersHCMVmaturational cleavageInhibitorinhibitorinhibit

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