2. Apoptosis
  3. TNF Receptor Apoptosis
  4. Benufutamab

Benufutamab  (Synonyms: GEN1029)

Cat. No.: HY-P99470 Purity: 98.62%
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Benufutamab (GEN1029) is a death receptor 5 (DR5)-specific agonistic antibody. Benufutamab is a mixture of 2 noncompeting DR5-specific IgG1 antibodies, each with an E430G mutation in the Fc domain. Benufutamab has antitumor effects.

For research use only. We do not sell to patients.

CAS No. : 2109730-69-8

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Based on 1 publication(s) in Google Scholar

Benufutamab Related Antibodies

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Description

Benufutamab (GEN1029) is a death receptor 5 (DR5)-specific agonistic antibody. Benufutamab is a mixture of 2 noncompeting DR5-specific IgG1 antibodies, each with an E430G mutation in the Fc domain. Benufutamab has antitumor effects[1].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species

Chimeric; Humanized
In Vitro

Benufutamab (GEN1029; HexaBody-DR5/DR5; 20 µg/mL; 24 hours) induces potent cytotoxicity in multiple myeloma (MM) cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Benufutamab Related Antibodies

Cell Viability Assay[1]

Cell Line: Multiple myeloma (MM) cells
Concentration: 20 µg/mL
Incubation Time: 24 hours
Result: Induced potent cytotoxicity.
In Vivo

Benufutamab (GEN1029; HexaBody-DR5/DR5; 0.5-2 mg/kg; i.p.; once a week; for 9 weeks) shows significant antitumor activity in PDX models for colorectal cancer[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Balb/c athymic nude or NU/NU nude mice injected with colorectal cancer (CRC) cells[2]
Dosage: 0.5 mg/kg, or 2 mg/kg
Administration: i.p.; once a week; for 9 weeks
Result: Showed significant antitumor activity.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Benufutamab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Purity & Documentation
References
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Benufutamab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Benufutamab2109730-69-8GEN1029GEN 1029GEN-1029TNF ReceptorApoptosisTumor Necrosis Factor ReceptorTNFRDR5E430Gantitumor effectsInhibitorinhibitorinhibit

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