2. GPCR/G Protein Epigenetics Cell Cycle/DNA Damage
  3. Adenosine Receptor PARP Aurora Kinase
  4. Benzo[c][1,8]naphthyridin-6(5H)-one

Benzo[c][1,8]naphthyridin-6(5H)-one exhibits low micromolar affinity to human adenosine receptor (AR) A1 and hA2A, with Ki of 4.6 and 4.8 μM. Benzo[c][1,8]naphthyridin-6(5H)-one is inhibitor for poly ADP-ribose polymerase-1 (PARP-1) and aurora kinase A, with IC50 of 0.311 and 5.5 μM.

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Benzo[c][1,8]naphthyridin-6(5H)-one Chemical Structure

Benzo[c][1,8]naphthyridin-6(5H)-one Chemical Structure

CAS No. : 53439-81-9

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Benzo[c][1,8]naphthyridin-6(5H)-one Related Antibodies

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Aurora Kinase Aurora A Aurora B Aurora C

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Description

Benzo[c][1,8]naphthyridin-6(5H)-one exhibits low micromolar affinity to human adenosine receptor (AR) A1 and hA2A, with Ki of 4.6 and 4.8 μM. Benzo[c][1,8]naphthyridin-6(5H)-one is inhibitor for poly ADP-ribose polymerase-1 (PARP-1) and aurora kinase A, with IC50 of 0.311 and 5.5 μM[1][2][3].

IC50 & Target

PARP-1

0.311 μM (IC50)

Aurora A

5.5 μM (IC50)

hA1AR

4.6 μM (Ki)

hA2AAR

4.8 μM (Ki)

Molecular Weight

196.20

Formula

C12H8N2O
CAS No.
SMILES

O=C1NC2=NC=CC=C2C3=CC=CC=C13
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Benzo[c][1,8]naphthyridin-6(5H)-one Related Classifications

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Keywords:

Benzo[c][1,8]naphthyridin-6(5H)-one53439-81-9Adenosine ReceptorPARPAurora KinaseP1 receptorpoly ADP ribose polymeraseHEK293strokeheart ischemiaMiaPaca-2Inhibitorinhibitorinhibit

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