2. PROTAC
  3. PROTAC Linkers
  4. Benzyl-PEG2-Tos

Benzyl-PEG2-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Benzyl-PEG2-Tos Chemical Structure

Benzyl-PEG2-Tos Chemical Structure

CAS No. : 98627-22-6

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500 mg USD 70 In-stock
1 g USD 111 Get quote
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Customer Review

Based on 1 publication(s) in Google Scholar

Benzyl-PEG2-Tos Related Antibodies

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Description

Benzyl-PEG2-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Benzyl-PEG2-Tos Related Antibodies
Molecular Weight

350.43

Formula

C18H22O5S
CAS No.
Appearance

Liquid

Color

Light yellow to yellow

SMILES

O=S(C1=CC=C(C)C=C1)(OCCOCCOCC2=CC=CC=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (285.36 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8536 mL 14.2682 mL 28.5364 mL
5 mM 0.5707 mL 2.8536 mL 5.7073 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.54%

SDS (392 KB)

COA (245 KB) HNMR (125 KB) RP-HPLC (95 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8536 mL 14.2682 mL 28.5364 mL 71.3409 mL
5 mM 0.5707 mL 2.8536 mL 5.7073 mL 14.2682 mL
10 mM 0.2854 mL 1.4268 mL 2.8536 mL 7.1341 mL
15 mM 0.1902 mL 0.9512 mL 1.9024 mL 4.7561 mL
20 mM 0.1427 mL 0.7134 mL 1.4268 mL 3.5670 mL
25 mM 0.1141 mL 0.5707 mL 1.1415 mL 2.8536 mL
30 mM 0.0951 mL 0.4756 mL 0.9512 mL 2.3780 mL
40 mM 0.0713 mL 0.3567 mL 0.7134 mL 1.7835 mL
50 mM 0.0571 mL 0.2854 mL 0.5707 mL 1.4268 mL
60 mM 0.0476 mL 0.2378 mL 0.4756 mL 1.1890 mL
80 mM 0.0357 mL 0.1784 mL 0.3567 mL 0.8918 mL
100 mM 0.0285 mL 0.1427 mL 0.2854 mL 0.7134 mL
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Benzyl-PEG2-Tos Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Benzyl-PEG2-Tos98627-22-6PROTAC LinkersInhibitorinhibitorinhibit

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