2. Epigenetics
  3. Epigenetic Reader Domain
  4. BET-IN-7

BET-IN-7 (Compound 1) is a potent inhibitor of BET with a Ki and Kd of 12.27 and 89.3 μM, respectively. BET-IN-7 has the potential for the research of sepsis.

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BET-IN-7 Chemical Structure

BET-IN-7 Chemical Structure

CAS No. : 303985-05-9

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BET-IN-7 Related Antibodies

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Description

BET-IN-7 (Compound 1) is a potent inhibitor of BET with a Ki and Kd of 12.27 and 89.3 μM, respectively. BET-IN-7 has the potential for the research of sepsis[1].

Cellular Effect
Cell Line Type Value Description References
HEK293 IC50
27 nM
Compound: 1
Inhibition of human 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation plate reader
Inhibition of human 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation plate reader
[PMID: 21983444]
Molecular Weight

353.83

Formula

C18H12ClN3OS
CAS No.
SMILES

N#CC1=C(N=C(NC1=O)SCC2=CC=CC=C2Cl)C3=CC=CC=C3
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BET-IN-7 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BET-IN-7303985-05-9Epigenetic Reader DomainBETLPS-inducedsepsisInhibitorinhibitorinhibit

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