Betahistine-d₃ dihydrochloride

Name: Betahistine-d 3 dihydrochloride
Brand: MedChemExpress
SKU: HY-B0524AS
Rating: 4.5 (1 reviews)

Cat. No.: HY-B0524AS Purity: ≥99.0%: FAQs
Data Sheet SDS COA Handling Instructions

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Betahistine-d₃ (dihydrochloride) is the deuterium labeled Betahistine dihydrochloride. Betahistine dihydrochloride is an orally active histamine H1 receptor agonist and a H3 receptor antagonist[1]. Betahistine dihydrochloride is used for the study of rheumatoid arthritis (RA)[3].

For research use only. We do not sell to patients.

Betahistine-d<sub>3</sub> dihydrochloride Chemical Structure

Betahistine-d₃ dihydrochloride Chemical Structure

CAS No. : 244094-72-2

Size	Price	Stock	Quantity
1 mg	USD 170	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 490	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 780	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of Betahistine-d₃ dihydrochloride:

Betahistine dihydrochloride In-stock
β-Histine-d3 Get quote

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•Related Small Molecules:

•Related Proteins:

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H₁ Receptor H₂ Receptor H₃ Receptor H₄ Receptor Histamine Receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

212.13

Formula

C₈H₁₁D₃Cl₂N₂

CAS No.

244094-72-2

Unlabeled CAS

5579-84-0

Appearance

Solid

Color

Off-white to light yellow

SMILES

[2H]C([2H])([2H])NCCC1=CC=CC=N1.Cl.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : ≥ 50 mg/mL (235.70 mM)

DMSO : 33.33 mg/mL (157.12 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMF : 5 mg/mL (23.57 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.7141 mL	23.5705 mL	47.1409 mL
5 mM	0.9428 mL	4.7141 mL	9.4282 mL
10 mM	0.4714 mL	2.3570 mL	4.7141 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥99.0%

Select Batch:

Data Sheet (273 KB) SDS (251 KB)

COA (249 KB) Elemental Analysis Report (107 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Poyurovsky M, et al. The effect of betahistine, a histamine H1 receptor agonist/H3 antagonist, on olanzapine-induced weight gain in first-episode schizophrenia patients. Int Clin Psychopharmacol. 2005 Mar;20(2):101-3. [Content Brief]

[3]. Gbahou F, et al. Effects of betahistine at histamine H3 receptors: mixed inverse agonism/agonism in vitro and partial inverse agonism in vivo.J Pharmacol Exp Ther. 2010 Sep 1;334(3):945-54. [Content Brief]

[4]. Tang KT, et al. Betahistine attenuates murine collagen-induced arthritis by suppressing both inflammatory and Th17 cell responses.Int Immunopharmacol. 2016 Oct;39:236-245. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMF / DMF / DMSO / DMSO / H₂O / H₂O	1 mM	4.7141 mL	23.5705 mL	47.1409 mL	117.8523 mL
	5 mM	0.9428 mL	4.7141 mL	9.4282 mL	23.5705 mL
	10 mM	0.4714 mL	2.3570 mL	4.7141 mL	11.7852 mL
	15 mM	0.3143 mL	1.5714 mL	3.1427 mL	7.8568 mL
	20 mM	0.2357 mL	1.1785 mL	2.3570 mL	5.8926 mL
DMSO / DMSO / H₂O / H₂O	25 mM	0.1886 mL	0.9428 mL	1.8856 mL	4.7141 mL
	30 mM	0.1571 mL	0.7857 mL	1.5714 mL	3.9284 mL
	40 mM	0.1179 mL	0.5893 mL	1.1785 mL	2.9463 mL
	50 mM	0.0943 mL	0.4714 mL	0.9428 mL	2.3570 mL
	60 mM	0.0786 mL	0.3928 mL	0.7857 mL	1.9642 mL
	80 mM	0.0589 mL	0.2946 mL	0.5893 mL	1.4732 mL
	100 mM	0.0471 mL	0.2357 mL	0.4714 mL	1.1785 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.