Betazole dihydrochloride (Synonyms: Ametazole dihydrochloride)

Cat. No.: HY-B1557A: FAQs
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Betazole (Ametazole) dihydrochloride, a pyrazole analogue of histamine, is an orally active H2 receptor agonist. Betazole dihydrochloride induces gastric acid secretion, and causes an immediate and significant increase in common bile duct pressure. Betazole dihydrochloride has been used as a diagnostic agent known as histalog, for investigating gastric acid secretory capacity.

For research use only. We do not sell to patients.

Betazole dihydrochloride Chemical Structure

CAS No. : 138-92-1

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Other Forms of Betazole dihydrochloride:

Betazole Get quote

1 Publications Citing Use of MCE Betazole dihydrochloride

•Proc Natl Acad Sci U S A. 2023 Feb 28;120(9):e2207003120. [Abstract]

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H₁ Receptor H₂ Receptor H₃ Receptor H₄ Receptor Histamine Receptor

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Description

IC₅₀ & Target^[1]

H₂ Receptor

In Vitro

Betazole (Ametazole) dihydrochloride is a weak histamine agonist with relative selectivity towards H2 receptors and only minimal H1 activity. Betazole dihydrochloride induces gastric inhibitory polypeptide (GIP) secretion^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

184.07

Formula

C₅H₁₁Cl₂N₃

CAS No.

138-92-1

SMILES

NCCC1=NNC=C1.[H]Cl.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Maples MD, Effects of betazole hydrochloride and cimetidine on common bile pressure and duodenal myoelectric activity in the dog. Am Surg. 1981;47(12):519-521. [Content Brief]

[2]. Spitz IM, Betazole-induced GIP secretion is not mediated by gastric HCl. Metabolism. 1982;31(4):380-382. [Content Brief]

[3]. CLAYMAN CB,. A simple oral gastric secretory stimulant (betazole hydrochloride). JAMA. 1961;175:908-909. [Content Brief]

Betazole dihydrochloride Related Classifications

Metabolic Disease

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Betazole138-92-1AmetazoleHistamine ReceptorhistaloggastricacidsecretionbileductpressuresecretorycapacityInhibitorinhibitorinhibit

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