Betulinic acid derivative-1

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Betulinic acid derivative-1 exhibits distinguished activities on inhibiting osteoclast (OC) differentiation with an IC₅₀ value of 1.86 μM.

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Betulinic acid derivative-1 Chemical Structure

CAS No. : 2708127-92-6

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Description

Betulinic acid derivative-1 exhibits distinguished activities on inhibiting osteoclast (OC) differentiation with an IC₅₀ value of 1.86 μM.

Cellular Effect

Cell Line	Type	Value	Description	References
RAW264.7	IC₅₀	1.86 μM Compound: 25	Inhibition of RANKL/M-CSF-induced osteoclastogenesis in mouse RAW264.7 cells measured for 4 days by TRAP staining based assay Inhibition of RANKL/M-CSF-induced osteoclastogenesis in mouse RAW264.7 cells measured for 4 days by TRAP staining based assay	[PMID: 34491054]
RAW264.7	CC₅₀	16.18 μM Compound: 25	Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay	[PMID: 34491054]
RAW264.7	IC₅₀	2.32 μM Compound: 25	Antiinflammatory activity against LPS-induced mouse RAW264.7 cells assessed as reduction in IL-1beta production incubated for 48 hrs by ELISA analysis Antiinflammatory activity against LPS-induced mouse RAW264.7 cells assessed as reduction in IL-1beta production incubated for 48 hrs by ELISA analysis	[PMID: 34491054]
RAW264.7	IC₅₀	21.41 μM Compound: 25	Antiinflammatory activity against LPS-induced mouse RAW264.7 cells assessed as reduction in TNF-alpha production incubated for 48 hrs by ELISA analysis Antiinflammatory activity against LPS-induced mouse RAW264.7 cells assessed as reduction in TNF-alpha production incubated for 48 hrs by ELISA analysis	[PMID: 34491054]
RAW264.7	CC₅₀	5.77 μM Compound: 25	Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability measured for 96 hrs by MTT assay Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability measured for 96 hrs by MTT assay	[PMID: 34491054]
RAW264.7	IC₅₀	8.1 μM Compound: 25	Antiinflammatory activity against LPS-induced mouse RAW264.7 cells assessed as reduction in IL-6 production incubated for 48 hrs by ELISA analysis Antiinflammatory activity against LPS-induced mouse RAW264.7 cells assessed as reduction in IL-6 production incubated for 48 hrs by ELISA analysis	[PMID: 34491054]

Molecular Weight

560.90

Formula

C₃₇H₆₀N₄

CAS No.

2708127-92-6

SMILES

CN(CC1)CCC1CN[C@]23[C@@]([C@@H](CC3)C(C)=C)([H])[C@]4([H])[C@@](CC2)([C@]5([C@]([C@@]6([C@@](C(C)(C7=NNC=C7C6)C)([H])CC5)C)([H])CC4)C)C

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wang J, et al. Synthesis and Biological Evaluation of C-17-Amino-Substituted Pyrazole-Fused Betulinic Acid Derivatives as Novel Agents for Osteoarthritis Treatment. J Med Chem. 2021 Sep 23;64(18):13676-13692. [Content Brief]