2. Immunology/Inflammation Metabolic Enzyme/Protease
  3. IFNAR CD74 NO Synthase Arginase
  4. BG-136

BG-136 is an innate immune stimulant isolated from Durvillaea Antarctica that can simultaneously stimulate the activation of both innate and adaptive immune cells in the tumor microenvironment (TME), exerting a broad-spectrum antitumor effect.

For research use only. We do not sell to patients.

BG-136 Chemical Structure

BG-136 Chemical Structure

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BG-136 Related Antibodies

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Description

BG-136 is an innate immune stimulant isolated from Durvillaea Antarctica that can simultaneously stimulate the activation of both innate and adaptive immune cells in the tumor microenvironment (TME), exerting a broad-spectrum antitumor effect[1].

In Vivo

BG136 (0.3 mg/kg, i.v. twice a week) is capable of inhibiting tumor growth in vivo in the C57BL/6 J mouse colorectal cancer (CRC) cell line MC38 syngeneic tumor model, without observed weight loss[1].
BG136 (0.3 mg/kg, i.v. twice a week) enhances the tumor inhibitory effect of the anti-PD1 antibody, resulting in more effective tumor growth inhibition, when used in combination with anti-PD1 antibody (200 μg per mouse, i.v. once a week) in the MC38 syngeneic tumor model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MC38 syngeneic tumor C57BL/6 J mice model[1].
Dosage: 0.3 mg/kg
Administration: i.v. twice a week alone, or BG136 in combination with PD1 antibody (200 μg per mouse, i.v. once a week)
Result: Significantly increased the infiltration of total CD45+ immune cells and CD8+ T cells in the tumor microenvironment (TME), as well as the proportion of cells expressing tumor necrosis factor α (TNFα) and granzyme B.
Significantly upregulated the antigen-presenting related genes CD74, H2-Ab1, and CD8b1, as well as the pro-inflammatory cytokine IFNγ.
Led to a significant decrease in Ki67 expression, indicating the inhibition of cell proliferation in the tumor microenvironment (TME), when used in combination with anti-PD1 antibody.
Was able to induce the gene expression of the pro-inflammatory cytokines IFNγ and TNFα, as well as the expression of the antitumor M1-like macrophage marker gene iNOS, and inhibit the expression of the tumor-promoting M2-like macrophage marker Arginase 1, when used in combination with anti-PD1 antibody.
Molecular Weight

4000-7000

SMILES

[BG-136]
Structure Classification
Initial Source

Durvillaea antarctica
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BG-136 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BG-136BG136BG 136IFNARCD74NO SynthaseArginaseInterferon-α/β receptorInterferon-alpha/beta receptor HLA-DR-gammaInvariant polypeptide of major histocompatibility complex, class II antigen-associatedNitric oxide synthasesNOSImmune systemTumor microenvironmentAnti-tumoImmunotherapyTranscriptomicsC57BL/6 J miceColorectal cancer (CRC)MC38Inhibitorinhibitorinhibit

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