2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. BI-2493

BI-2493 is a structural analogue of BI-2865 and a highly selective and orally active pan-KRAS inhibitor. BI-2493 can attenuate tumor growth. BI-2493 can be used for cancer iseases research.

For research use only. We do not sell to patients.

BI-2493 Chemical Structure

BI-2493 Chemical Structure

CAS No. : 2937344-16-4

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1 mg USD 760 In-stock
5 mg USD 1880 In-stock
10 mg USD 2700 In-stock
25 mg USD 3600 In-stock
50 mg USD 4900 In-stock
100 mg USD 6500 In-stock
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Based on 1 publication(s) in Google Scholar

BI-2493 Related Antibodies

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K-Ras H-Ras N-Ras Ras

  • Biological Activity

  • Purity & Documentation

  • References

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Description

BI-2493 is a structural analogue of BI-2865 and a highly selective and orally active pan-KRAS inhibitor. BI-2493 can attenuate tumor growth. BI-2493 can be used for cancer iseases research[1].

IC50 & Target

K-Ras WT

 

In Vitro

BI-2493 (0-10 μM, 72 h) inhibits the proliferation of KRAS mutant cancer cell lines in a concentration-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BI-2493 Related Antibodies

Cell Viability Assay[1]

Cell Line: ASPC1 cells (G12D), HPAC cells (G12D), H727 cells (G12V) (BaF3 cells transduced with a virus derived from plasmids expressing KRAS G12D or G12V mutants)
Concentration: 0, 100 nM, 1000 nM, 10000 nM
Incubation Time: 72 h
Result: Effectively inhibited the proliferation of cancer cells ASPC1 (G12D), HPAC (G12D), and H727 (G12V)
In Vivo

BI-2493 (90 mg/kg, p.o., twice daily for 21 days) exhibits tumor-suppressive activity in LS513/GP2d/HPAC/SW620/MIAPACA2-derived xenograft NMRI mice models[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: LS513/GP2d/HPAC/SW620/MIAPACA2-derived xenograft NMRI mice models
Dosage: 90 mg/kg
Administration: Oral gavage (p.o.), twice daily for 21 days
Result: Reduced tumor growth in mice carrying KRAS G12C, G12D, G12V, and A146V mutation models, without causing significant toxicity to the mice.
Molecular Weight

461.58

Formula

C24H27N7OS
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

N#CC1=C(N)SC2=C1[C@]3(CCC2)C4=C(CCC3)C(C5=NC(N6[C@H](CNCC6)C)=NC=C5)=NO4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (108.32 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1665 mL 10.8324 mL 21.6647 mL
5 mM 0.4333 mL 2.1665 mL 4.3329 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.79%

COA (253 KB) HNMR (139 KB) LCMS (93 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1665 mL 10.8324 mL 21.6647 mL 54.1618 mL
5 mM 0.4333 mL 2.1665 mL 4.3329 mL 10.8324 mL
10 mM 0.2166 mL 1.0832 mL 2.1665 mL 5.4162 mL
15 mM 0.1444 mL 0.7222 mL 1.4443 mL 3.6108 mL
20 mM 0.1083 mL 0.5416 mL 1.0832 mL 2.7081 mL
25 mM 0.0867 mL 0.4333 mL 0.8666 mL 2.1665 mL
30 mM 0.0722 mL 0.3611 mL 0.7222 mL 1.8054 mL
40 mM 0.0542 mL 0.2708 mL 0.5416 mL 1.3540 mL
50 mM 0.0433 mL 0.2166 mL 0.4333 mL 1.0832 mL
60 mM 0.0361 mL 0.1805 mL 0.3611 mL 0.9027 mL
80 mM 0.0271 mL 0.1354 mL 0.2708 mL 0.6770 mL
100 mM 0.0217 mL 0.1083 mL 0.2166 mL 0.5416 mL
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BI-2493 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BI-24932937344-16-4BI2493BI 2493RasASPC1 cells (G12D)HPAC cells (G12D)H727 cells (G12V)Anti-cancer activityInhibitorinhibitorinhibit

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