2. Immunology/Inflammation
  3. STING
  4. BI 7446

BI 7446 is a cyclic dinucleotide (CDN)-based potent and selective stimulator of interferon genes (STING) agonist. BI 7446 can activate all five STING variants in cells and induce tumor-specific immune-mediated tumor rejection. BI 7446 can be used for immuno-oncology research.

For research use only. We do not sell to patients.

BI 7446 Chemical Structure

BI 7446 Chemical Structure

CAS No. : 2767011-00-5

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BI 7446 Related Antibodies

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Description

BI 7446 is a cyclic dinucleotide (CDN)-based potent and selective stimulator of interferon genes (STING) agonist. BI 7446 can activate all five STING variants in cells and induce tumor-specific immune-mediated tumor rejection. BI 7446 can be used for immuno-oncology research[1].

In Vitro

BI 7446 (CDN13) (3 μM, 10 μM, 6 h) increases IRF3 and TBK1 phosphorylation in THP1 STING-wild type cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BI 7446 Related Antibodies

Western Blot Analysis[1]

Cell Line: wild type and STING-knock out THP1 cells
Concentration: 3 μM, 10 μM
Incubation Time: 6 h
Result: Observed a dose dependent increase of IRF3 and TBK1 phosphorylation in THP1 wild type cells but not in THP1 STING knockout cells.
In Vivo

BI 7446 (CDN13) (4, 12, 36 μg for intravenous injection, 0-25 h for detection time) has a high plasma clearance and a short elimination half-life in 4T1 BALB/c mouse tumor model[1].
BI 7446 (0.25, 1, 4 μg for subcutaneous injection, once weekly) generates tumor regression and a long-term immunologic memory against autologous tumor re-challenge in EMT6 mouse breast cancer model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 4T1 BALB/c mouse tumor model [1]
Dosage: 4, 12, 36 μg
Administration: Intravenous injection (i.v.)
Result: Observed a high plasma clearance and a short elimination half-life.
Animal Model: EMT6 mouse breast cancer model[1]
Dosage: 0.25, 1, 4 μg
Administration: Subcutaneous injection (s.c.)
Result: Observed dose-dependent tumor regression even at the lowest tested dose.
Impaired the growth of the EMT6 tumors.
Molecular Weight

693.52

Formula

C20H22FN9O10P2S2
CAS No.
SMILES

O[C@H]1[C@@H](O2)[C@H](N3C(C=NNC4=O)=C4N=C3)O[C@@H]1CO[P@](O[C@H]5[C@@H](F)[C@H](N6C(N=CN=C7N)=C7N=C6)O[C@@H]5CO[P@]2(S)=O)(S)=O
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BI 7446 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BI 74462767011-00-5BI7446BI-7446STINGStimulator of Interferon GenesTMEM173MITAERISMPYScancerimmune systemInhibitorinhibitorinhibit

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