2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. BIBX 1382 dihydrochloride

BIBX 1382 dihydrochloride is an ErbB kinase inhibitor with significant antiviral activity. BIBX 1382 affects the ability of viruses to enter host cells by inhibiting members of the ErbB kinase family. It can be used to study the interaction mechanism between virus and host and the broad spectrum intervention of highly pathogenic viruses.

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BIBX 1382 dihydrochloride Chemical Structure

BIBX 1382 dihydrochloride Chemical Structure

CAS No. : 1216920-18-1

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BIBX 1382 dihydrochloride Related Antibodies

Top Publications Citing Use of Products

    BIBX 1382 dihydrochloride purchased from MedChemExpress. Usage Cited in: Neuroscience. 2015 Jul 20;304:109-121.  [Abstract]

    GluN2B Y1472 phosphorylation in whole-cell lysate is increased after 5 and 10 min of EGF treatment in cultured neurons which could be blocked by BIBX-1382. EGFR activation increases SFK activity and phosphorylation of GluN2B Y1472. (A) Representative Western blot result of whole lysate samples from hippocampal slices treated with 50 ng/mL EGF incubation for 10 min. (B) Western blot of EGFR-treated DIV14 cultured hippocampal neurons with minimum glia composition shows increased phosphorylation of

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    Description

    BIBX 1382 dihydrochloride is an ErbB kinase inhibitor with significant antiviral activity. BIBX 1382 affects the ability of viruses to enter host cells by inhibiting members of the ErbB kinase family. It can be used to study the interaction mechanism between virus and host and the broad spectrum intervention of highly pathogenic viruses[1].

    Molecular Weight

    460.76

    Formula

    C18H21Cl3FN7
    CAS No.
    SMILES

    CN(CC1)CCC1NC2=NC(C(NC3=CC(Cl)=C(F)C=C3)=NC=N4)=C4C=N2.Cl.Cl
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    BIBX 1382 dihydrochloride Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    BIBX 13821216920-18-1BIBX1382BIBX-1382EGFREpidermal growth factor receptorErbB-1HER1Antiviral activitykinase inhibitorErbBInhibitorinhibitorinhibit

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