2. GPCR/G Protein
  3. GPR171
  4. BigLEN(mouse)

BigLEN(mouse) is a potent and selective agonist of orphan G protein-coupled receptor 171 (GPR171), with a Kd of ∼0.5 nM. BigLEN(mouse) can be used to regulate responses associated with food intake and metabolism.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

BigLEN(mouse) Chemical Structure

BigLEN(mouse) Chemical Structure

CAS No. : 501036-69-7

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1 mg USD 180 In-stock
5 mg USD 540 In-stock
10 mg USD 850 In-stock
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Based on 1 publication(s) in Google Scholar

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BigLEN(mouse) Related Antibodies

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Description

BigLEN(mouse) is a potent and selective agonist of orphan G protein-coupled receptor 171 (GPR171), with a Kd of ∼0.5 nM. BigLEN(mouse) can be used to regulate responses associated with food intake and metabolism[1][2].

IC50 & Target

Kd: ∼0.5 nM (GPR171)[1]
Molecular Weight

1756.01

Formula

C78H130N24O22
CAS No.
Appearance

Solid

Color

White to off-white

Sequence Shortening

LENPSPQAPARRLLPP
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (56.95 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.5695 mL 2.8474 mL 5.6947 mL
5 mM 0.1139 mL 0.5695 mL 1.1389 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.98%

SDS (252 KB)

COA (261 KB) RP-HPLC (199 KB) Elemental Analysis Report (120 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.5695 mL 2.8474 mL 5.6947 mL 14.2368 mL
5 mM 0.1139 mL 0.5695 mL 1.1389 mL 2.8474 mL
10 mM 0.0569 mL 0.2847 mL 0.5695 mL 1.4237 mL
15 mM 0.0380 mL 0.1898 mL 0.3796 mL 0.9491 mL
20 mM 0.0285 mL 0.1424 mL 0.2847 mL 0.7118 mL
25 mM 0.0228 mL 0.1139 mL 0.2278 mL 0.5695 mL
30 mM 0.0190 mL 0.0949 mL 0.1898 mL 0.4746 mL
40 mM 0.0142 mL 0.0712 mL 0.1424 mL 0.3559 mL
50 mM 0.0114 mL 0.0569 mL 0.1139 mL 0.2847 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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BigLEN(mouse) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BigLEN(mouse)501036-69-7GPR171G Protein-Coupled Receptor 171orphanGproteincoupledfoodintakemetabolismInhibitorinhibitorinhibit

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