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BIM5078 is a hepatocyte nuclear factor 4α (HNF4α) antagonist that can inhibit the expression of known HNF4α target genes. BIM5078 represses insulin promoter activity through HNF4α antagonism. BIM5078 can be used for the research of cancer and diabetes.

For research use only. We do not sell to patients.

BIM5078 Chemical Structure

BIM5078 Chemical Structure

CAS No. : 337506-43-1

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BIM5078 Related Antibodies

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Description

BIM5078 is a hepatocyte nuclear factor 4α (HNF4α) antagonist that can inhibit the expression of known HNF4α target genes. BIM5078 represses insulin promoter activity through HNF4α antagonism. BIM5078 can be used for the research of cancer and diabetes[1].

IC50 & Target

hepatocyte nuclear factor 4α (HNF4α)[1]
In Vitro

BIM5078 (0.63-5μM; 48 h) inhibits the expression of endogenous insulin in T6PNE cells with IC50 value of 930 nM[1].
BIM5078 (2.5-10 μM; 5-48 h) inhibits HNF4α gene expression in HepG2 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BIM5078 Related Antibodies
Molecular Weight

351.76

Formula

C14H10ClN3O4S
CAS No.
SMILES

[O-][N+](C1=CC=C(C(S(=O)(N2C3=C(N=C2C)C=CC=C3)=O)=C1)Cl)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BIM5078 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BIM5078337506-43-1BIM 5078BIM-5078OthersHNF4αAntagonistT6PNEInhibitorinhibitorinhibit

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