4-trimethylaminobutyraldehyde dehydrogenase

Definition:

Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine with high efficiency (in vitro). Can catalyze the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction, but with low efficiency.

References:

[1]. Radka Končitíková, et al. Kinetic and structural analysis of human ALDH9A1. Biosci Rep. 2019 Apr 26;39(4):BSR20190558. [Content Brief]

[2]. A Kikonyogo, et al. Aldehyde dehydrogenase from adult human brain that dehydrogenates gamma-aminobutyraldehyde: purification, characterization, cloning and distribution. Biochem J. 1996 May 15;316 ( Pt 1)(Pt 1):317-24. [Content Brief]

[3]. F M Vaz, et al. Molecular and biochemical characterization of rat gamma-trimethylaminobutyraldehyde dehydrogenase and evidence for the involvement of human aldehyde dehydrogenase 9 in carnitine biosynthesis. J Biol Chem. 2000 Mar 10;275(10):7390-4. [Content Brief]

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