A disintegrin and metalloproteinase with thrombospondin motifs 12

Definition:

Metalloprotease that may play a role in the degradation of COMP. Cleaves also alpha-2 macroglobulin and aggregan. Has anti-tumorigenic properties.

References:

[1]. Chuan-ju Liu, et al. ADAMTS-12 associates with and degrades cartilage oligomeric matrix protein. J Biol Chem. 2006 Jun 9;281(23):15800-8. [Content Brief]

[2]. Y Luan, et al. Inhibition of ADAMTS-7 and ADAMTS-12 degradation of cartilage oligomeric matrix protein by alpha-2-macroglobulin. Osteoarthritis Cartilage. 2008 Nov;16(11):1413-20. [Content Brief]

[3]. María Llamazares, et al. The ADAMTS12 metalloproteinase exhibits anti-tumorigenic properties through modulation of the Ras-dependent ERK signalling pathway. J Cell Sci. 2007 Oct 15;120(Pt 20):3544-52. [Content Brief]

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