A disintegrin and metalloproteinase with thrombospondin motifs 2

Definition:

Cleaves the propeptides of type I and II collagen prior to fibril assembly (By similarity). Does not act on type III collagen (By similarity). Cleaves lysyl oxidase LOX at a site downstream of its propeptide cleavage site to produce a short LOX form with reduced collagen-binding activity.

References:

[1]. Tamara Rosell-García, et al. Differential cleavage of lysyl oxidase by the metalloproteinases BMP1 and ADAMTS2/14 regulates collagen binding through a tyrosine sulfate domain. J Biol Chem. 2019 Jul 19;294(29):11087-11100. [Content Brief]

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