A-kinase anchor protein 7 isoforms alpha and beta

Definition:

Targets the cAMP-dependent protein kinase (PKA) to the plasma membrane, and permits functional coupling to the L-type calcium channel. The membrane-associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium.

References:

[1]. I D Fraser, et al. A novel lipid-anchored A-kinase Anchoring Protein facilitates cAMP-responsive membrane events. EMBO J. 1998 Apr 15;17(8):2261-72. [Content Brief]

[2]. Abderrahmane Bengrine, et al. The A-kinase anchoring protein 15 regulates feedback inhibition of the epithelial Na+ channel. FASEB J. 2007 Apr;21(4):1189-201. [Content Brief]

[3]. K W Trotter, et al. Alternative splicing regulates the subcellular localization of A-kinase anchoring protein 18 isoforms. J Cell Biol. 1999 Dec 27;147(7):1481-92. [Content Brief]

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