Abdominal obesity-metabolic syndrome

Definition:

Abdominal obesity-metabolic syndrome (AOMS) is also known as syndrome X or insulin resistance syndrome. Insulin resistance is a key abnormality associated with an atherogenic, prothrombotic, and inflammatory profile. The most prevalent form of this constellation of metabolic abnormalities is found in patients with abdominal obesity, especially with an excess of intra-abdominal or visceral adipose tissue. Recently, a few causative gene mutations have been reported.

References:

[1]. Ali R Keramati, et al. A form of the metabolic syndrome associated with mutations in DYRK1B. N Engl J Med. 2014 May 15;370(20):1909-1919. [Content Brief]

[2]. Fatemehsadat Esteghamat, et al. CELA2A mutations predispose to early-onset atherosclerosis and metabolic syndrome and affect plasma insulin and platelet activation. Nat Genet. 2019 Aug;51(8):1233-1243. [Content Brief]

[3]. G M Reaven, et al. Role of insulin resistance in human disease (syndrome X): an expanded definition. Annu Rev Med. 1993;44:121-31. [Content Brief]

[4]. Jean-Pierre Després, et al. Abdominal obesity and the metabolic syndrome: contribution to global cardiometabolic risk. Arterioscler Thromb Vasc Biol. 2008 Jun;28(6):1039-49. [Content Brief]

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