Abnormal spindle-like microcephaly-associated protein

Definition:

Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex. May have a preferential role in regulating neurogenesis.

References:

[1]. Jacquelyn Bond, et al. ASPM is a major determinant of cerebral cortical size. Nat Genet. 2002 Oct;32(2):316-20. [Content Brief]

[2]. Kai Jiang, et al. Microtubule minus-end regulation at spindle poles by an ASPM-katanin complex. Nat Cell Biol. 2017 May;19(5):480-492. [Content Brief]

[3]. Natalay Kouprina, et al. The microcephaly ASPM gene is expressed in proliferating tissues and encodes for a mitotic spindle protein. Hum Mol Genet. 2005 Aug 1;14(15):2155-65. [Content Brief]

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