Acetyl-CoA carboxylase 1

Definition:

Cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis. This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA.

References:

[1]. Moritz Hunkeler, et al. Structural basis for regulation of human acetyl-CoA carboxylase. Nature. 2018 Jun;558(7710):470-474. [Content Brief]

[2]. Christopher L Colbert, et al. Crystal structure of Spot 14, a modulator of fatty acid synthesis. Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):18820-5. [Content Brief]

[3]. Chai-Wan Kim, et al. Induced polymerization of mammalian acetyl-CoA carboxylase by MIG12 provides a tertiary level of regulation of fatty acid synthesis. Proc Natl Acad Sci U S A. 2010 May 25;107(21):9626-31. [Content Brief]

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