Acetyl-coenzyme A synthetase, cytoplasmic

Definition:

Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids. Acetate is the preferred substrate. Can also utilize propionate with a much lower affinity (By similarity).

References:

[1]. A Luong, et al. Molecular characterization of human acetyl-CoA synthetase, an enzyme regulated by sterol regulatory element-binding proteins. J Biol Chem. 2000 Aug 25;275(34):26458-66. [Content Brief]

[2]. Yukihiro Yoshimura, et al. Molecular cloning of rat acss3 and characterization of mammalian propionyl-CoA synthetase in the liver mitochondrial matrix. J Biochem. 2017 Mar 1;161(3):279-289. [Content Brief]

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