Acetylcholine receptor subunit epsilon

Definition:

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

References:

[1]. Xin-Ming Shen, et al. Mutations Causing Slow-Channel Myasthenia Reveal That a Valine Ring in the Channel Pore of Muscle AChR is Optimized for Stabilizing Channel Gating. Hum Mutat. 2016 Oct;37(10):1051-9. [Content Brief]

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