Acidic leucine-rich nuclear phosphoprotein 32 family member A

Definition:

Multifunctional protein that is involved in the regulation of many processes including tumor suppression, apoptosis, cell cycle progression or transcription. Promotes apoptosis by favouring the activation of caspase-9/CASP9 and allowing apoptosome formation. In addition, plays a role in the modulation of histone acetylation and transcription as part of the INHAT (inhibitor of histone acetyltransferases) complex. Inhibits the histone-acetyltranferase activity of EP300/CREBBP (CREB-binding protein) and EP300/CREBBP-associated factor by histone masking. Preferentially binds to unmodified histone H3 and sterically inhibiting its acetylation and phosphorylation leading to cell growth inhibition. Participates in other biochemical processes such as regulation of mRNA nuclear-to-cytoplasmic translocation and stability by its association with ELAVL1 (Hu-antigen R). Plays a role in E4F1-mediated transcriptional repression as well as inhibition of protein phosphatase 2A.; (Microbial infection) Plays an essential role in influenza A, B and C viral genome replication. Mechanistically, mediates the assembly of the viral replicase asymmetric dimers composed of PB1, PB2 and PA via its N-terminal region. Also plays an essential role in foamy virus mRNA export from the nucleus.

References:

[1]. J Bai, et al. Tumor suppression and potentiation by manipulation of pp32 expression. Oncogene. 2001 Apr 19;20(17):2153-60. [Content Brief]

[2]. Loïc Carrique, et al. Host ANP32A mediates the assembly of the influenza virus replicase. Nature. 2020 Nov;587(7835):638-643. [Content Brief]

[3]. Jochen Bodem, et al. Foamy virus nuclear RNA export is distinct from that of other retroviruses. J Virol. 2011 Mar;85(5):2333-41. [Content Brief]

[4]. Marija Cvetanovic, et al. The role of LANP and ataxin 1 in E4F-mediated transcriptional repression. EMBO Rep. 2007 Jul;8(7):671-7. [Content Brief]

[5]. J R Brody, et al. Identification of sequences required for inhibition of oncogene-mediated transformation by pp32. J Biol Chem. 1999 Jul 16;274(29):20053-5. [Content Brief]

[6]. Rachid Mazroui, et al. Caspase-mediated cleavage of HuR in the cytoplasm contributes to pp32/PHAP-I regulation of apoptosis. J Cell Biol. 2008 Jan 14;180(1):113-27. [Content Brief]

[7]. Xiuli Wei, et al. The interaction of cellular protein ANP32A with influenza A virus polymerase component PB2 promotes vRNA synthesis. Arch Virol. 2019 Mar;164(3):787-798. [Content Brief]

[8]. Aldo R Camacho-Zarco, et al. Molecular basis of host-adaptation interactions between influenza virus polymerase PB2 subunit and ANP32A. Nat Commun. 2020 Jul 21;11(1):3656. [Content Brief]

[9]. Sang-beom Seo, et al. Regulation of histone acetylation and transcription by nuclear protein pp32, a subunit of the INHAT complex. J Biol Chem. 2002 Apr 19;277(16):14005-10. [Content Brief]

[10]. Zhenyu Zhang, et al. Selective usage of ANP32 proteins by influenza B virus polymerase: Implications in determination of host range. PLoS Pathog. 2020 Oct 12;16(10):e1008989. [Content Brief]

[11]. Hyun-Eui Kim, et al. PHAPI, CAS, and Hsp70 promote apoptosome formation by preventing Apaf-1 aggregation and enhancing nucleotide exchange on Apaf-1. Mol Cell. 2008 Apr 25;30(2):239-47. [Content Brief]

[12]. Z Fan, et al. Tumor suppressor pp32 represses cell growth through inhibition of transcription by blocking acetylation and phosphorylation of histone H3 and initiating its proapoptotic activity. Cell Death Differ. 2006 Sep;13(9):1485-94. [Content Brief]

[13]. Ichiro Tsujio, et al. Inhibitors of protein phosphatase-2A from human brain structures, immunocytological localization and activities towards dephosphorylation of the Alzheimer type hyperphosphorylated tau. FEBS Lett. 2005 Jan 17;579(2):363-72. [Content Brief]

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