Activating signal cointegrator 1 complex subunit 2

Definition:

Plays a role in DNA damage repair as component of the ASCC complex. Recruits ASCC3 and ALKBH3 to sites of DNA damage by binding to polyubiquitinated proteins that have 'Lys-63'-linked polyubiquitin chains. Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation. Involved in activation of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation. As part of the ribosome quality control trigger (RQT) complex, recognizes ZNF598-dependent ubiquitination of stalled ribosomes (By similarity).

References:

[1]. Dong-Ju Jung, et al. Novel transcription coactivator complex containing activating signal cointegrator 1. Mol Cell Biol. 2002 Jul;22(14):5203-11. [Content Brief]

[2]. Joshua R Brickner, et al. A ubiquitin-dependent signalling axis specific for ALKBH-mediated DNA dealkylation repair. Nature. 2017 Nov 16;551(7680):389-393. [Content Brief]

[3]. Satoshi Hashimoto, et al. Identification of a novel trigger complex that facilitates ribosome-associated quality control in mammalian cells. Sci Rep. 2020 Feb 25;10(1):3422. [Content Brief]

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