Acylamino-acid-releasing enzyme

Definition:

This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus. It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser.

References:

[1]. R Erlandsson, et al. The gene from the short arm of chromosome 3, at D3F15S2, frequently deleted in renal cell carcinoma, encodes acylpeptide hydrolase. Oncogene. 1991 Jul;6(7):1293-5. [Content Brief]

[2]. W M Jones, et al. Genetic relationship between acylpeptide hydrolase and acylase, two hydrolytic enzymes with similar binding but different catalytic specificities. Proc Natl Acad Sci U S A. 1991 Mar 15;88(6):2194-8. [Content Brief]

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