Adapter SH3BGRL

Definition:

Appears to function as an adapter protein that bridges proteins together or proteins with mRNAs. May function as a ubiquitin ligase-substrate adapter. Additionally, associates with translating cytoplasmic ribosomes and may promote the expression of specific mRNAs.

References:

[1]. Shaoyang Zhang, et al. Adaptor SH3BGRL promotes breast cancer metastasis through PFN1 degradation by translational STUB1 upregulation. Oncogene. 2021 Sep;40(38):5677-5690. [Content Brief]

[2]. Shaoyang Zhang, et al. Adaptor SH3BGRL drives autophagy-mediated chemoresistance through promoting PIK3C3 translation and ATG12 stability in breast cancers. Autophagy. 2022 Aug;18(8):1822-1840. [Content Brief]

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