Adenomatous polyposis coli protein 2

Definition:

Stabilizes microtubules and may regulate actin fiber dynamics through the activation of Rho family GTPases. May also function in Wnt signaling by promoting the rapid degradation of CTNNB1.

References:

[1]. C R Jarrett, et al. Human APC2 localization and allelic imbalance. Cancer Res. 2001 Nov 1;61(21):7978-84. [Content Brief]

[2]. Mariam Almuriekhi, et al. Loss-of-Function Mutation in APC2 Causes Sotos Syndrome Features. Cell Rep. 2015 Mar 10;10(9):1585-1598. [Content Brief]

[3]. J H van Es, et al. Identification of APC2, a homologue of the adenomatous polyposis coli tumour suppressor. Curr Biol. 1999 Jan 28;9(2):105-8. [Content Brief]

[4]. H Nakagawa, et al. Identification of a brain-specific APC homologue, APCL, and its interaction with beta-catenin. Cancer Res. 1998 Nov 15;58(22):5176-81. [Content Brief]

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