Adenylate kinase isoenzyme 5

Definition:

Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Active on AMP and dAMP with ATP as a donor. When GTP is used as phosphate donor, the enzyme phosphorylates AMP, CMP, and to a small extent dCMP. Also displays broad nucleoside diphosphate kinase activity.

References:

[1]. Nicola Solaroli, et al. Identification of two active functional domains of human adenylate kinase 5. FEBS Lett. 2009 Sep 3;583(17):2872-6. [Content Brief]

[2]. Marjan Amiri, et al. The human adenylate kinase 9 is a nucleoside mono- and diphosphate kinase. Int J Biochem Cell Biol. 2013 May;45(5):925-31. [Content Brief]

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