Adhesion G protein-coupled receptor G3

Definition:

Orphan receptor that regulates migration of lymphatic endothelial cells in vitro via the small GTPases RhoA and CDC42. Regulates B-cell development (By similarity). Seems to signal through G-alpha(q)-proteins.

References:

[1]. Jamila Gupte, et al. Signaling property study of adhesion G-protein-coupled receptors. FEBS Lett. 2012 Apr 24;586(8):1214-9. [Content Brief]

[2]. Nadejda Valtcheva, et al. The orphan adhesion G protein-coupled receptor GPR97 regulates migration of lymphatic endothelial cells via the small GTPases RhoA and Cdc42. J Biol Chem. 2013 Dec 13;288(50):35736-48. [Content Brief]

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