Adiponectin deficiency

Definition:

Adiponectin is a major adipocyte-derived protein with insulin-sensitizing, anti-inflammatory and anti-atherogenic properties. Adiponectin deficiency related to several obesity related malignancies including colorectal cancer.

References:

[1]. Arpit Saxena, et al. Adiponectin deficiency: role in chronic inflammation induced colon cancer. Biochim Biophys Acta. 2012 Apr;1822(4):527-36. [Content Brief]

[2]. Naoto Kubota, et al. Disruption of adiponectin causes insulin resistance and neointimal formation. J Biol Chem. 2002 Jul 19;277(29):25863-6. [Content Brief]

[3]. Toshimasa Yamauchi, et al. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature. 2003 Jun 12;423(6941):762-9. [Content Brief]

[4]. Toshimasa Yamauchi, et al. Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis. J Biol Chem. 2003 Jan 24;278(4):2461-8. [Content Brief]

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