Adiponectin receptor protein 1

Definition:

Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism. Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin (By similarity).

References:

[1]. Hiroaki Tanabe, et al. Crystal structures of the human adiponectin receptors. Nature. 2015 Apr 16;520(7547):312-316. [Content Brief]

[2]. Toshimasa Yamauchi, et al. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature. 2003 Jun 12;423(6941):762-9. [Content Brief]

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