ADP-ribosylation factor-like protein 4A

Definition:

Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form.

References:

[1]. C Y Lin, et al. ARL4, an ARF-like protein that is developmentally regulated and localized to nuclei and nucleoli. J Biol Chem. 2000 Dec 1;275(48):37815-23. [Content Brief]

[2]. Irmgard Hofmann, et al. The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane. Curr Biol. 2007 Apr 17;17(8):711-6. [Content Brief]

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